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Gene variant in TBI patients may cause psychiatric disorders

Traumatic brain injuries have been known to increase the risk for psychiatric disorders like PTSD, anxiety and depression. For example, the Minneapolis VA Center for Chronic Disease Outcomes Research found that out of the 13,000 veterans it analyzed, 80 percent who incurred a TBI were also diagnosed with a psychiatric disorder. TBI patients in Nevada should know that a new study has discovered a gene variant that can worsen those conditions.

The study was conducted by the Veterans Affairs San Diego Healthcare System and published online in the Journal of Neurotrauma. Researchers found that Apolipoprotein E, a protein responsible for the growth and repair of neurons, can create more severe psychiatric distress when found in the APOE4 gene variant. After testing the DNA of 133 Iraq/Afghanistan veterans, they found that 79 had mild or moderate TBI. Among the 79, those with the APOE4 gene were found to have higher symptom scores for PTSD, anxiety and depression.

Fatal pedestrian accidents on the rise

Many people in Las Vegas like to get around by walking. However, the threat of injuries or fatalities due to pedestrian accidents has made crossing the street more dangerous. Indeed, thousands of people across the country lose their lives each year while walking along the roadways. Both walkers and drivers can be prone to distraction, a situation that can have devastating consequences. In 2017 alone, nearly 6,000 pedestrians lost their lives due to car accidents.

This statistic is part of a recent increase in pedestrian accidents, something that some safety experts attribute to the rise of smartphones as well as the widespread use and legalization of marijuana. While some speculate that there is an increase in drivers under the influence of cannabis, many people who would not drive after using marijuana may be willing to take a walk outside. In addition, distracting smartphone use is a major concern, especially among drivers. While drivers have the responsibility to avoid crashes, however, pedestrians can also help to protect themselves.

About NDAs

Nevada residents who use a non-disclosure agreement, or an NDA, may be using the legal document for their business dealings in the wrong way. There should be careful consideration given to whether an NDA is necessary, and if it is, whether the NDA that is needed should be a two-way NDA.

As a legal agreement, an NDA requires that the parties involved adhere to their obligations as specified in the agreement. While NDAs generally do not have disclaimers regarding consequential damage, breaches of confidentiality are addressed in the consequential damage disclaimers that are a part of the operative document to which the parties may agree. As a result, any party that is in breach of an NDA may be financially liable for damages.

SUVs could be responsible for pedestrian death increase

According to the National Highway Traffic Safety Administration (NHTSA), there has been a 46 percent increase in pedestrian deaths since 2009. Between 2009 and 2016, there has been an 81 percent rise in pedestrian deaths caused by SUVs according to the Insurance Institute for Highway Safety (IIHS). Those who are at the most risk for being killed in a collision with an SUV are in warmer climates and in cities where individuals have lower incomes.

This is because they are the areas in which more people are likely to be in the street. SUVs tend to be more dangerous to pedestrians because they are larger and heavier than other vehicles. In Detroit, a quarter of people who were killed in motor vehicle accidents in 2017 were pedestrians. This is because there are few crosswalks and it can be hard to see in certain areas of the city.

Safety group wants to eliminate all traffic deaths

Traffic deaths in Nevada and throughout the country could be eliminated by 2050 according to a group called the Road to Zero Coalition. It wants to accomplish this goal by implementing a variety of reforms and innovative solutions. For example, it wants to increase seat belt use from 90 percent to 100 percent. While this seems like a small gain, half of traffic deaths are to those who don't wear a seat belt.

Both passenger vehicles and large trucks can be made safer in an effort to eliminate traffic deaths. For instance, the Insurance Institute for Highway Safety has suggested that rear underride guard regulations be imposed. In 2016, there were 4,317 deaths caused by accidents involving large trucks. Of those accidents, 80 percent were caused by trucks with a weight of 26,000 pounds. Another suggestion presented by Road to Zero is to make better use of technology when building roads and vehicles.

Study looks at white matter changes after a mild TBI

About 1.7 million people sustain a traumatic brain injury in the United States each year, according to the Centers for Disease Control and Prevention. Of those TBIs, an estimated 75 percent are classified as mild. However, Nevada residents or others who experience a head injury could suffer from significant symptoms such as headaches or dizziness for weeks or longer. In an effort to provide better diagnoses of mild TBIs, researchers recently studied the white matter of male college football and rugby players.

White matter was observed in study participants by using an MRI process called multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT). Participants included 11 football players and one rugby player who had experienced mild TBIs and 10 others who had not been injured and did not participate in contact sports. Participants were examined within 72 hours of their diagnoses and again three months later.

Succession concerns for businesses

Business owners in Nevada who are thinking about moving on to the next phase of their lives have many factors to consider before ding so. Based on information from the California Association of Business Brokers, over 12 million businesses are owned by baby boomers who may be ready to transition into retirement.

Many business owners may run into difficulties if they try to exit their family business without having a well-crafted strategy. The plan can protect the future of the business and the financial security of their family.

Study suggests that distracted driving laws are ineffective

Nevada is one of 15 states to have passed legislation banning the use of cell phones and other mobile electronic devices by drivers, but a recent study from a road safety analytics company suggests that even the harshest distracted driving laws are largely ineffective. The figures also suggest that the problem of distracted driving in the United States is far more serious than safety groups or government agencies imagine.

The National Highway Traffic Safety Administration has estimated that about 660,000 American drivers use cell phones while behind the wheel every day, but the Zendrive study, which was based on anonymized consumer data, suggests that the true figure could be as high as 69 million. This would mean that as many as 6 out of 10 motorists engage in this potentially deadly behavior on a daily basis.

Lawsuit claims tourist injured at David Copperfield show

On April 13, opening statements were heard in a civil trial brought by a man who alleges he suffered injuries in a fall while participating in magician David Copperfield's Las Vegas show in 2013. Both Copperfield and MGM Grand casino are named as defendants in the case.

According to the lawsuit, the plaintiff was randomly selected to assist Copperfield during the final trick of his performance at MGM Grand on Nov. 12, 2013. The illusion appears to make a person disappear from a platform on the main stage and reappear in the rear of the theater. The plaintiff's attorney said that his client, a British tourist, was not warned of any dangers when he agreed to participate in the act and trusted that Copperfield would protect him.

A business plan can include an exit strategy

Entrepreneurs in Las Vegas starting a new small business may be concerned about how to form the business in order to be appealing to investors. Investors who want to achieve a significant benefit from a new business may be looking toward the exit strategy in order to determine whether an investment is a good fit. For many small business founders, the most common thoughts about an exit strategy can be particularly dramatic: for example, a lucrative buyout from a major tech company or going public on the stock market with an initial public offering (IPO).

However, many companies never reach that stage at all; for tech start-ups, in particular, businesses that form with the best of intentions may gradually dwindle away, bleeding cash as they go. Others may work to develop steady profitability, but this outcome could be less appealing to investors looking for significant returns. While acquisition can be a major way for businesses to achieve large returns, making certain decisions during the business formation and planning process can help small companies to improve their chance for a sale.

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